By Anthony T. Campagnoni
The entire tissues of the attention, together with the lens, the cornea, the ciliary physique, the neuroretina and the retinal pigment epithelium needs to paintings in concord for the conclusion of transparent imaginative and prescient. The phenotypic emergence of every of those tissues calls for intercellular conversation, that is completed via direct actual touch in addition to via diffusion and reception of the molecular beacons. This quantity offers an summary of the molecular and mobile biology of eye improvement and encompasses subject matters like early gene expression within the floor ectoderm and the optic cup, retinal neurogenesis, signaling molecules and axonal tips. It provides new findings at the impact of the lens at the improvement of the visible process and the way gene expression within the optic cup controls differentiation of the lens fiber phone whereas tested rules concerning the morphogenesis of the ciliary physique are challenged. this can be a invaluable resource of knowledge for developmental biologists and neurobiologists.
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Extra resources for Development Of The Visual System (Developmental Neuroscience)
CP95 (p) and CP49 (t) transcripts are not observed in malformed lens, whereas they are detectable in the control lens (n, r). Hoechst staining is used to visualize the cell nuclei (c, f, i, l). Green ﬂuorescence of GFP indicates transgene expression in NR tissues (a, d, g, j, m, o, q, s). Bar = 100 m. Fig. 4. Expression analysis of FGF8 in the manipulated eye. Cryosection from embryo (stage 24) electroporated with dominantnegative Pax6 was subjected to in situ hybridization using FGF8 (a–c) probes.
3p, t), suggesting that the initiation of ﬁber cell differentiation was prematurely arrested in the deformed lens. , 2000], in the deformed optic cup. In situ hybridization (ﬁg. 4a– c) showed no expression of FGF8 in the deformed optic cup at stage 24 (ﬁg. 4b). In the control eyes, FGF8 reactivity was localized to the central portion of the NR opposing the lens (ﬁg. 4c, arrow). To understand the earlier expression proﬁle of this molecule under experimental condition, we examined the embryos after 24 h of electroporation, that is, at stage 17.
2003]. All these results indicate that FGFs are important for lens ﬁber differentiation. , 2000], which again deﬁnes a role for FGF8 in lens induction and differentiation in vivo and also shows a regulatory link between FGF8 and L-Maf. In this study, we have found that initial L-Maf expression is nearly normal in the lens placode of the Pax6negative-OV eye (ﬁg. 2j). This was anticipated, as Pax6 expression was not inactivated in the HE, yielding levels of Pax6 sufﬁcient to trigger the expression of lens ectoderm genes in response to early inductive signals from the OV.