Cytokine Inhibitors by Gennaro Ciliberto

By Gennaro Ciliberto

Compiling an up to date and targeted survey of the function cytokines play in cell-to-cell conversation, improvement, and differentiation, this accomplished reference highlights the clinical benefits of cytokine inhibition and pursues novel tools of discovery for stronger and particular blockading brokers. Investigates the pathogenic position of cytokines and the potential for cytokine inhibitors as anti inflammatory, anticancer, antiviral brokers! Written via 25 famous specialists revealing contemporary breakthroughs in examine, Cytokine Inhibitorsillustrates circumstances of certainly produced or in vitro engineered polypeptide cytokine blockading brokers describes all attainable ways to cytokine inhibitors, together with monoclonal antibodies, soluble receptors, engineered mutant cytokines, and small-molecular-weight receptor antagonists and signaling inhibitors basically explains the homeostatic functionality of cytokine inhibition and verifies healing techniques effecting average responses in organisms discusses the result of scientific trials and healing functions of first-generation recombinant receptor antagonists, resembling the potential for tumor necrosis issue antagonists as famous instruments within the treatment of persistent inflammatory stipulations concentrates at the medical improvement of second-generation small-molecular-weight, orally bioavailable cytokine inhibitors stories the enhanced realizing of intracellular signaling pathways, the structural determinants liable for cytokine-receptor interplay lists the 3-dimensional constitution, proper receptors, and intracellular tyrosine kinases of cytokines and masses more!Containing over 1400 references in addition to tables and drawings, Cytokine Inhibitors serves as an exemplary reference for easy and medical immunologists; allergists; biochemists; pathologists, hematologists; experimental, mobile, and molecular biologists; rheumatologists; infectious illness experts; medicinal chemists; and clinical college and upper-level undergraduate and graduate scholars in those disciplines.

Show description

Read or Download Cytokine Inhibitors PDF

Best immunology books

Mucosal Vaccines

This finished, authoritative treatise covers all facets of mucosal vaccines together with their improvement, mechanisms of motion, molecular/cellular elements, and functional purposes. The contributing authors and editors of this distinct publication are rather well identified of their respective fields. Mucosal Vaccines is prepared in a special layout during which uncomplicated, medical, and functional facets of the mucosal immune method for vaccine improvement are defined and mentioned.

Gesund oder krank: Das Immunsystem entscheidet

Jeder Mensch verfügt über ein leistungsfähiges Immunsystem, das ihn sicher durch die ständig lauernden Gesundheitsgefahren der Umgebung leitet. Entgleist diese körpereigene Abwehr oder läßt ihre Einsatzfreude nach, wird der Mensch krank. Arnold Hilgers und Inge Hofmann zeigen, wie die moderne Medizin die Geheimnisse und methods dieser inneren Schutztruppen entschlüsselt hat und vielen Feinden des Immunsystems auf die Schliche gekommen ist.

ELISA: Methods and Protocols

This quantity is a realistic biochemical consultant to the Enzyme-Linked Immunosorbent Assay (ELISA), used to realize a goal substance in a liquid pattern. The ELISA is a vital and wide-spread diagnostic instrument in drugs, animal wellbeing and fitness, botany and caliber insurance techniques in foodstuff and beverage creation.

The Immune Synapse: Methods and Protocols

This quantity presents the entire crucial protocols which are at present used to review the immune synapse. Chapters within the Immune Synapse: tools and Protocols conceal tools for the learn of the dynamics of immune synapse meeting, site visitors on the immune synapse, new excessive solution imaging, biophysical and computational equipment for the examine of the immune synapse, effector immune synapses, B phone, NK and mast telephone immune synapses, and immune interactions in vivo.

Additional info for Cytokine Inhibitors

Sample text

88. 89. 90. 91. 92. 93. 94. 95. 96. 97. 98. 99. and Dlnarello K Torigoe, S Ushio, T Okura, S Kobayashi, M Taniai, T Kunikate, T Murakami, 0 Sanou, H Kojima, M Fuji, T Ohta, M Ikeda, H Ikegami, M Kurimoto. Purification and characterization of the human interleukin-l8 receptor. J Biol Chem 272125737-25742, 1997. P Parnet, KE Garka, TP Bonnert, SK Dower, JE Sims. L-1Rrp is a novel receptor-like molecule similar to the type I interleukin-l receptor and its homologues TI/ST2 and IL- IR AcP. J Biol Chem 271:3967-3970, 1996.

J lmmunol 144: 2216-2222, 1990. 8. HJ Andrews, RA Bunning, CA Dinarello, RG Russell. Modulation of human chondrocyte metabolism by recombinant human interferon gamma: in-vitro effects on basal and IL-l-stimulated proteinase production, cartilage degradation and DNA synthesis. Biochim Biophys Acta 1012:128-134, 1989. 1. 24Fantuzzl and Dinarello 9. HJ Andrews, RA Bunning, TA Plumpton, IM Clark, RC Russell, TE Cawston. Inhibition of interleukin-l-induced collagenase production in human articular chondrocytes in vitro by recombinant human interferon-gamma.

J Exp Med 170:1409-1414, 1989. H Engelmann, D Novick, D Wallach. Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors. J Biol Chem 265: 1531-1536, 1990. D Novick, B Cohen, M Rubinstein. The human interferon alp receptor: characterization and molecular cloning. Cell 77:391-400, 1994. D Novick, H Engelmann, D Wallach, 0 Leitner, M Revel, M Rubinstein. Purification of soluble cytokine receptors from normal human urine by ligandaffinity and immunoaffinity chromatography.

Download PDF sample

Rated 4.30 of 5 – based on 27 votes