By Claus Cursiefen, Albert S. Jun
This ebook offers cutting-edge details on smooth minimally invasive lamellar transplant innovations for Fuchs endothelial dystrophy (FED), similar to Descemet stripping computerized endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). as well as transparent step by step descriptions of systems, assistance is on the market on donor tissue instruction, capability intra- and postoperative problems, and trouble administration. destiny cures within the type of clinical, cell-based ways also are mentioned. to accomplish the image, correct info is incorporated at the pathophysiology, medical beneficial properties, and differential analysis of FED. This booklet might be of curiosity to all who desire to find out about the dramatic advancements in corneal transplantation and clinical therapy which are remodeling the administration of FED.
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Extra info for Current Treatment Options for Fuchs Endothelial Dystrophy
47. Siddiqui S, Zenteno JC, Rice A, Chacon-Camacho O, Naylor SG, Rivera-de la Parra D, Spokes DM, James N, Toomes C, Inglehearn CF, Ali M. Congenital hereditary endothelial dystrophy caused by SLC4A11 mutations progresses to Harboyan syndrome. Cornea. 2014;33(3): 247–51. 48. Schmidt E, Lisch W, Philipp W, Lechner S, Göttinger W, Schlötzer-Schrehardt U, Müller T, Utermann G, Janecke AR. A new X-linked endothelial corneal dystrophy. Am J Ophthalmol. 2006;141(3):478–87. 49. Naumann GOH, Schlötzer-Schrehardt U.
2011;52(6):3391–7. 10-6165. 10-6165 [pii]. 38. Okumura N, Minamiyama R, Ho LT, Kay EP, Kawasaki S, Tourtas T, Schlotzer-Schrehardt U, Kruse FE, Young RD, Quantock AJ, Kinoshita S, Koizumi N. Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy. Lab Invest. 2015. 111. 39. Weber JA, Baxter DH, Zhang SL, Huang DY, Huang KH, Lee MJ, Galas DJ, Wang K. The MicroRNA spectrum in 12 body fluids. Clin Chem. 2010;56(11):1733–41. 147405. 40. Sheinerman KS, Umansky SR.
Best-corrected visual acuity (BCVA) 2. Difference of BCVA between morning (typically worse due to closed eyelids overnight) and afternoon 3. Subjective glare (0, +, ++, +++) especially at night 4. , Pentacam or anterior segment OCT) 5. Endothelial cell morphology (pleomorphism, polymegalism) (specular microscopy or confocal microscopy) 6. BUT NOT “endothelial cell count,” because this very much depends on the investigator and is notoriously overestimating the amount of the endothelium, strongly depending on where the “region of interest (ROI)” is placed  These criteria are also important for judging whether cataract surgery is still a reasonable option in FECD.