Ophthalmology

Current research in head and neck cancer: molecular by Henning Bier

By Henning Bier

The improvement of head and neck melanoma is a multistep strategy within which genetic in addition to epigenetic adjustments intrude with the common features of proto-oncogenes and tumor suppressor genes. furthermore, carcinogenesis is promoted by means of the impairment of mechanisms accountable for the upkeep of genetic balance. the buildup of the most important occasions reminiscent of evasion of apoptosis, loss of senescence, deregulated proliferation, invasion and metastasis, in addition to neoangiogenesis finally determines the malignant phenotype. The sixteen articles of this quantity span from advances within the realizing of underlying molecular pathways (conditional mouse version, folate task, DNA fix, genomic heterogeneity, p53 kin, human papillomavirus), to preclinical and medical reports investigating strength novel healing ambitions.

Show description

Read or Download Current research in head and neck cancer: molecular pathways, novel therapeutic targets, and prognostic factors PDF

Best ophthalmology books

Current Concepts in Uveal Melanoma (Developments in Ophthalmology)

Uveal cancer is an competitive type of melanoma which may contain the iris, the ciliary physique, and/or the choroid, that is the most place of this tumor. sufferers usually desire to learn approximately remedy offerings and the result of varied ways. vital present scientific questions are no matter if a biopsy might be taken of choroidal melanomas, what could be performed with this biopsy, and even if high-risk sufferers may be screened frequently.

Anterior Segment Diseases (Instant Clinical Diagnosis in Ophthalmology)

The newest instructions for diagnosing and treating corneal ailments This well-illustrated full-color reference offers the most recent directions for diagnosing and treating corneal ailments. positive factors: Full-color presentation with a variety of illustrations presents whole up-to-date info on every kind of anterior phase ailments With in-depth concentration, the authors be aware of very important components of the skin abnormalities, together with pathology of tear movie, illness of conjunctiva, eyelids, and tumors offers up-to-date directions to set up quick and proper medical prognosis for correct and well timed remedy of corneal illnesses

2014-2015 Basic and Clinical Science Course (BCSC): Section 7: Orbit Eyelids and Lacrimal System

Information the anatomy of the orbit and adnexa, and emphasizes a pragmatic method of the review and administration of orbital and eyelid issues, together with malpositions and involutional adjustments. Updates present info on congenital, inflammatory, infectious, neoplastic and worrying stipulations of the orbit and accent constructions.

Ophthalmic surgical procedures

Authored by means of world-renowned eye surgeons and lecturers, the second one variation of this booklet is a step by step advisor to universal eye surgical procedure and laser approaches. The publication opens via reviewing the basics of ophthalmic surgical procedure. Chapters are then grouped into separate sections that handle cataracts, corneal illnesses, refractive surgical procedure, eye trauma, glaucoma, oculoplastics, pediatric ophthalmology and strabismus, and vitreoretinal illnesses.

Extra info for Current research in head and neck cancer: molecular pathways, novel therapeutic targets, and prognostic factors

Example text

To understand the impact of DNA repair genes in the estimation of genetic risk and in the development of laryngeal cancer we attempted to study the distribution of 3 polymorphic DNA repair genes. To choose the most representative genes it was decided to focus on XPD, XRCC1 and XRCC3. The chosen genes take part in the 3 major mechanisms of DNA repair involved in the removal of DNA lesions induced by tobacco smoke carcinogens, namely nucleotide excision repair (XPD), base excision repair (XRCC1) and recombination repair Gajecka/Rydzanicz/Jaskuta-Sztul/Wierzbicka/Szyfter/Szyfter 34 (XRCC3), but a cross-participation is not excluded [24].

Contributed equally to this work and should be considered as first author. Primary and advanced head and neck squamous cell carcinomas (HNSCCs) are characterized by complex karyotypes with multiple chromosome aberrations and cytogenetically different subclones [1–3]. This intratumoral heterogeneity can be explained by selective growth advantage of certain cells with slightly varying karyotypes (related subclones) reflecting ongoing clonal evolution [4, 5]. Furthermore, prolonged exposure to carcinogenic agents such as tobacco can lead to the development of multiple synchronous or metachronous tumors with karyotypically unrelated subclones due to the hypothesis of ‘field cancerization’ [6].

Cancer Res 1996;56:4103–4107. Cheng L, Eicher SA, Guo Z, Hong WK, Spitz MR, Wei Q: Reduced DNA repair capacity in head and neck cancer patients. Cancer Epidemiol Biomarkers Prev 1998;7:465–468. Matullo G, Palli D, Peluso M, Guarrera A, Carturan S, Polidoro S, Munnia A, Krogh V, Masala G, Berrino F, Panico S, Tumino R, Vineis P: Combination of DNA repair gene single nucleotide polymorphisms and increased levels of DNA adducts in a population-based study. Cancer Epidemiol Biomarkers Prev 2003;12:674–677.

Download PDF sample

Rated 4.03 of 5 – based on 41 votes