By Gerd Burmester
Humboldt Univ., Berlin, Germany. Pocket-sized atlas illustrates the basic ideas of immunology and its scientific functions. positive factors greater than one hundred thirty colour plates describing uncomplicated ideas, laboratory diagnostics, and medical immunology. For physicians and citizens. Softcover.
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Extra resources for Color Atlas of Immunology
They are divided into four subclasses (IgG1, IgG2, IgG3, and IgG4) which are distinguished by differences in their c chains, as is denoted by the numerical suffixes c1 to c4. The heavy chains have one variable domain and three constant domains. The molecular weight of IgG amounts to a total of ca. 150 000 Da. The light chains (ca. 212 amino acids) contribute around 23 000 Da, and the heavy chains (ca. 450 amino acids) around 50 000±70 000 Da in the various subclasses. IgG3 is heavier than all other IgG subclasses because it contains a long series of disulfide bonds in the so-called hinge region.
70 000 Da). This involves a certain portion of the membrane receptor that binds IgA on the extraluminal side of the epithelial cell. The receptor undergoes cleavage, and the portion that was bound to IgA is released along with the immunoglobulin. Burmester, Color Atlas of Immunology © 2003 Thieme All rights reserved. Usage subject to terms and conditions of license. Immunoglobulin Classes Albumin Breast milk Globulins ! 2 " " # Fc receptors IgD IgA 1. Circulating Ig 2. Membrane2. bound Ig IgG A.
Idiotypic determinants are the individual determinants of any given antibody molecule in accordance with the variability of the immunoglobulin's CDR region. Burmester, Color Atlas of Immunology © 2003 Thieme All rights reserved. Usage subject to terms and conditions of license. Immunoglobulins Variable Constant Domain C1q binding site Light chain CH1 VH Heavy chain S S S S S CH2 COOH S S CH3 CH1 COOH VH CH2 CL NH2 CH3 CL Fc Antigen binding Effector function CDR = complementarity-determining region Fab = antigen-binding fragment Fc = crystallizable fragment CH4 Only at IgE and IgM VL VL Fab NH2 SSSS S Antigen binding VH = variable domain of heavy chains VL = variable domain of light chains CH/L = constant domain of heavy / light chains A.