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Circulation in Skeletal Muscle. Proceedings of an by O. Hudlicka

By O. Hudlicka

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Extra resources for Circulation in Skeletal Muscle. Proceedings of an International Symposium Held at Smolenice, Czechoslovakia, 1966

Sample text

L . , GREEN, H . D . and DENISON, A. B . (1955) Nature of the vasodilator and vasoconstrictor receptors in skeletal muscle of the dog. Circulation Res. 3 , 171-180. DISCUSS ION Dr. e. the neuroeffector junctions, they make contact only with the advential surface of the outer smooth muscle layer of the vessels. Deeper layers lack a direct adrenergic nerve supply. , the umbilical vessels, which lack adrenergic innervation, that they respond poorly or not at all t o noradrenaline. In other words, it might be so that significant amounts of alpha receptors are present only where there are also adrenergic nerve endings.

Under these circumstances the equilibrium level o f anesthesia is not identical in all animals. We have not specifically studied the influence of depth of anesthesia on reflex vasodilation: but if the eff'ect on other drug-induced reflex changes is anything to go by, depth of anesthesia influences the response not only quantitatively,, but qualitatively as well. Dr. F o L K O w : I asked this, because with this type of aff'erent stimulation you probably cause a mass activation of diff'erent types of aff'erent fibres.

N G A I Department of Pharmacology, Karolinska Institutet, Stockholm 60, Sweden THE skeletal muscle blood vessels are innervated by adrenergic vasoconstrictor and cholinergic vasodilator fibres. e. precapillary resistance vessels (arterioles), precapillary sphincters and postcapillary resistance and capacitance vessels, whereas the vasodilator nerves seem to innervate only the precapillary resistance vessels (Mellander, 1960; Folkov^, Mellander and Oberg, 1961; Rosell and Uvnäs, 1962; Renkin and Rosell, 1962).

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