Chemistry

Chemokine Receptors in Cancer by Chareeporn Akekawatchai, Marina Kochetkova, Jane Holland

By Chareeporn Akekawatchai, Marina Kochetkova, Jane Holland (auth.), Amy M. Fulton (eds.)

Chemokine Receptors in melanoma summarizes the transforming into physique of facts that a number of chemokine receptors give a contribution to tumor habit. Chemokine receptors have been first pointed out on leukocytes and mediate directed migration of many host cells to websites of ligand expression. it really is now good tested that the majority malignant cells additionally convey a number of chemokine receptor. This ebook describes our present figuring out relating to how chemokine receptors give a contribution to tumor phone migration in addition to telephone survival and proliferation. The functionality of chemokine receptors expressed on host cells together with antitumor immune effector cells in addition to angiostatic and angiogeneic features of chemokines performing on endothelial cells are defined. The position of chemokine receptors that act as decoy receptors can be summarized. The healing strength and demanding situations of concentrating on chemokine receptors or cognate ligands can also be addressed.

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