Chemistry and Brain Development: Proceedings of the Advanced by J. Folch-Pi (auth.), Rodolfo Paoletti, Alan N. Davison

By J. Folch-Pi (auth.), Rodolfo Paoletti, Alan N. Davison (eds.)

J. Folch-Pi Director of clinical study, McLean health center, Belmont, Mass., U.S.A. the advance of the vital anxious procedure is very likely the main major point of the expansion of a mammal from embryo to maturity. The significant frightened method is clearly the most repository not just of the species' inherited useful features but additionally of the method of individuation. no matter what "engrams" represent the root of person features are laid down frequently within the imperative apprehensive process, and particularly the mind, in the course of its progress. The chemical point of this procedure is obviously of serious value and the importance of its learn may be self glaring. however, it is just one point of a parel lei sequence of morphological, physiological, biochemical and mental occasions which occur as an built-in strategy, the ultimate results of that's the transformation of the post-embryonic frightened approach into the functioning grownup method. it truly is vital, hence, that any examine or description of the chemical occasions through the improvement of the CNS could be undertaken in ful I wisdom of the concomitant morphological, physiological and mental occasions. it's only by contrast multidiscipl inary informational framework that the chemical occasions in the course of 2 J. FOLCH-PI improvement may be properly interpreted and procure their ful I importance. With this in brain, the creation to this quantity may well top serve its function by means of describing in short the morphological and physiological occasions that accompany the chemical point of development.

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Extra resources for Chemistry and Brain Development: Proceedings of the Advanced Study Institute on “Chemistry of Brain Development,” held in Milan, Italy, September 9–19, 1970

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Protozoology 15:600 (1968). 13. Conner, R. , Mallory, F. , Landrey, J. , and Iyengar, C. W. L. J. Bio1. , 244:2325 (1969). 14. Koro1y, M. J. and Dempsey, M. E. in preparation. BIOSYNTHESIS OF STEROLS IN DEVELOPING BRAIN E. Grossi Paoletti Institute of Pharmacology, University of Mi Ian 20129 Mi lan, Italy During development brain tissue actively synthesizes cholesterol to meet the requirements necessary for formation of its structures (I, 2). The biosynthetic activity in brain varies from species to species, according to the sequence of the developmental stages and is higher during the period of maximal brain growth (3).

In fact, a correlation exists between the eSF concentration of desmosterol and the 60 R. FUMAGALLI TABLE 2. AVERAGE CSF CONCENTRATIONS OF CHOLESTEROL AND DESMOSTEROL IN PATIENTS TREATED WITH TRIPARANOL PATI ENTS No. OF CASES }J CHOLESTEROL g/ m I ~ S. E. }J DESMOSTEROL g/ m I ~ S. E. 82 presence of a brain tumor (18) (Table 2). The origin of CSF desmosterol could be due either to a passage of the sterol from the blood through an altered blood-brain barrier or to endogenous formation of desmosterol in the tumor (19) which is then released into CSF, or to both these possibi I ities.

Stein, A. in Regional Neurochemistry (Eds. S. Kety and J. C. Thomas, Springfield (1961) 4. o I son, 5. D. J. Neurochem. lQ: 135 (1963) 6. T. (1961 ) 7. N. in Adv. Lipid Research vol. 3 (Eds. D. Kritchevsky and R. Paoletti) Academic Press (1965) 8. , and Garattini, S. Arch. Biochem. Biophys. 99:529 ( 1962) 9. J. J. Lipid Res. 10: 166 (1969) Arch. J. A. Er~. Physiol. Bioi. Chemie und Exp. Pharmako I. 56: 163 (1965) 1:298 J. Neurochem. 10. , and Menkes, J. H. 243:3884 (1968) J. Bi 0 I. Chem. II.

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