Browse Category by Immunology
Immunology

Gene Therapy for HIV Infection by Clay Smith M.D. (auth.)

By Clay Smith M.D. (auth.)

ince the early Nineteen Eighties, the HIV epidemic has been raging in the S 1 usa and world wide. Drug treatment for HIV an infection has no longer been healing, prompting the quest for substitute thoughts to regulate HIV an infection inside contaminated individuals. One strength alterna­ tive to drug treatment is a constructing clinical expertise termed gene remedy. 2 Gene treatment includes introducing genetic components into popu­ lations of cells with the intention to right or hinder a pathologic technique. various gene treatment recommendations were built in an at­ tempt to inhibit HIV expression and unfold. those recommendations fall into basic different types, genetic amendment of cells with the intention to elicit an immune reaction opposed to HIV and genetic amendment of the objective cells of HIV an infection so that it will block HIV expression and copy. within the first approach, termed genetic immunotherapy by way of a few, genetic fabric encoding HIV proteins is brought into patient's cells which will stimulate a mobile immune reaction above and past three five that inspired by means of the viral an infection itself. - normal genetic im­ munotherapy concepts were built. Genes encoding HIV seasoned­ teins were without delay injected into the epidermis or muscle mass of sufferers. those genes were encoded in plasmids or viral DNA and feature been injected both within the kind of bare DNA or complexed with lipids.

Show description

Continue Reading

Immunology

Handbook of B and T Lymphocytes by E. Charles Snow

By E. Charles Snow

To bring together this up to date instruction manual, Dr. Charles Snow of the college of Kentucky scientific heart has assembled works by way of a finest workforce of lively investigators who meet the wishes of todays researchers. The handbookprovides a huge evaluation of the ancient and present learn in B- and T-cell biology, and offers the most recent advancements during this fast-breaking box to all pros considering the humoral immune reaction of the physique

Show description

Continue Reading

Immunology

Vaccine Adjuvants: Methods and Protocols by Christopher B. Fox

By Christopher B. Fox

This assortment seeks to clarify the sensible tools priceless for profitable adjuvant improvement, with a selected specialize in the synthesis, formula, production, and characterization features concerned. starting with an outline and a case research, the e-book then delves into in silico layout, chemical synthesis, biosynthesis, and/or purification from usual uncooked fabrics of particular adjuvant molecules, adjuvant formula methods, the analytical characterization of adjuvant formulations and adjuvant-containing vaccines, in addition to the organic characterization of vaccine adjuvant task, together with in vitro and in vivo methods, to degree innate and adaptive immune responses. Written within the hugely profitable Methods in Molecular Biology layout, chapters comprise introductions to their respective issues, lists of the mandatory fabrics and reagents, step by step, without difficulty reproducible laboratory protocols, and tips about troubleshooting and heading off recognized pitfalls.

Practical and authoritative, Vaccine Adjuvants: tools and Protocols goals to facilitate vaccine adjuvant product improvement efforts, making them extra available, manufacturable, and higher characterized.

Show description

Continue Reading

Immunology

C-Type Lectin Receptors in Immunity by Sho Yamasaki

By Sho Yamasaki

The ebook offers the most recent findings on C-type lectin receptors, concentrating on person receptors and their signaling. in recent times there were nice advances within the knowing of the functionality of those receptors as a newly rising relations of pattern-recognition receptors (PRRs) for pathogen-associated molecular styles (PAMPs) and damage-associated molecular styles (DAMPs). Comprising 4 elements: ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearing Receptors; and different Receptors and comparable subject matters, this finished evaluate covers a extensive variety of C-type lectin receptors. The up-to-date details on C-type lectin receptors and their ligands supplied will attract a large readership, from easy immunologists to physicians and surgeons. additionally, sections on novel drug improvement make this a worthwhile source for pharmaceutical scientists.

Show description

Continue Reading

Immunology

The Immune Synapse: Methods and Protocols by Cosima T. Baldari, Michael L. Dustin

By Cosima T. Baldari, Michael L. Dustin

This quantity presents the entire crucial protocols which are at the moment used to check the immune synapse. Chapters in The Immune Synapse: tools and Protocols hide tools for the examine of the dynamics of immune synapse meeting, site visitors on the immune synapse, new excessive solution imaging, biophysical and computational tools for the learn of the immune synapse, effector immune synapses, B cellphone, NK and mast cellphone immune synapses, and immune interactions in vivo. Written within the hugely winning Methods in Molecular Biology series layout, chapters comprise introductions to their respective themes, lists of the mandatory fabrics and reagents, step by step, simply reproducible laboratory protocols, and tips about troubleshooting and averting recognized pitfalls.

Authoritative and functional, The Immune Synapse: equipment and Protocols could be of curiosity to immunologists and, at a extra basic point, to cellphone biologists, biophysicists and computational biologists.

Show description

Continue Reading

Immunology

Kaplan Medical Step 1 Microbiology - Immunology by Kaplan Medical

By Kaplan Medical

The single official Kaplan Lecture Notes for USMLE Step 1 disguise the great info you want to ace the examination and fit into the residency of your choice.

* updated: up-to-date each year by way of Kaplan’s all-star faculty
* built-in: choked with medical correlations and bridges among disciplines
* Learner-efficient: geared up in define layout with high-yield precis boxes
* depended on: utilized by millions of scholars every year to be triumphant on USMLE Step 1

Show description

Continue Reading

Immunology

Advances in Tumor Immunology and Immunotherapy by Christos E. Kyriakopoulos, Alberto J. Montero, Claudia

By Christos E. Kyriakopoulos, Alberto J. Montero, Claudia Marcela Diaz-Montero (auth.), Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa (eds.)

Recent advances in realizing of basic immunology have created new insights into the dynamic interactions among tumors and the immune approach. This comprises new realizing of T- and B-cell interplay, immune inhibitory mechanisms together with the biology of T regulatory cells, myeloid suppressor cells, and dendritic cellphone subsets.

Enhanced realizing of mechanisms underlying T-cell anergy corresponding to arginine deprivation, immunosuppressive cytokines, faulty innate and interferon reaction pathways, and NKG2D downregulation have all supplied new perception into suppression of anti-tumor immunity and tumor evasion.

In addition to rising realizing of tumor evasion, new immune pursuits resembling CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all supply new probabilities for reinforcing anti-tumor immunity even in tumors formerly felt to be proof against immune assault. numerous of those recommendations have already been discovered within the health facility. the amount will discover evolving paradigms in antigen presentation, dendritic phone biology, the innate reaction and immunosuppressive mechanisms, and rising innovations for manipulation of the immune process for healing gain that experience learned good fortune in neuroblastoma, leukemia, cancer, lung melanoma, and allogeneic transplantation. Early successes in addition to mess ups can be highlighted to supply a photograph of the country of scientific immunotherapy with a watch to destiny percentages similar to mix remedies, adoptive T-cell move, and the retargeting of immune cells through T-cell receptor engineering.

Show description

Continue Reading

Immunology

Specialization and Complementation of Humoral Immune by Tim Manser

By Tim Manser

The value of particular antibodies for the clearance of and long term resistance to many infectious pathogens has lengthy been appreciated.

In the final 5 years, information from of all of those components of analysis have coalesced, leading to the emergence of a brand new and extra entire realizing of the way antibody-mediated resistance to pathogens is elaborated. the new explosion of information of Toll-like receptor (TLR) specificity and serve as (Takeda et al., 2003) has additional adorned this figuring out. it's now transparent that there's not just large overlap and cross-complementarity within the motion of innate and adaptive structures, but additionally specialization of functionality of a few of the B mobilephone subsets and the kinds of antibodies they produce. This synergistic interplay of a number of elements of those structures might be most sensible exemplified in antibody responses to micro organism. The members to this quantity will spotlight this new point of view on antibody responses to an infection, in addition to to exhibit its sensible implications, akin to for modern vaccine design.

Show description

Continue Reading