Cancer Vaccines: Challenges and Opportunities in Translation by Adrian Bot, Mihail Obrocea

By Adrian Bot, Mihail Obrocea

Recent advances in immunology and biology have opened new horizons in melanoma remedy, integrated within the increasing array of melanoma treatment plans, that are immunotherapies, or melanoma vaccines, for either sturdy and blood borne cancers. Cancer Vaccines: demanding situations and possibilities in Translation is the 1st textual content within the box to deliver immunotherapy remedies from the laboratory trial to the bedside for the working towards oncologist.

Cancer Vaccines: demanding situations and possibilities in Translation:

  • Critically analyzes the main promising sessions of investigational immunotherapies, integrating their clinical reason and scientific potential
  • Discusses "theranostics" as concerning immunotherapy, i.e., utilizing molecular diagnostics to spot sufferers that may probably take advantage of a therapy
  • Presents the hot paradigm of biomarker guided R&D and medical improvement in immunotherapy of cancer
  • Reviews bottlenecks in translational strategy of immunotherapies and gives thoughts to unravel them

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Additional resources for Cancer Vaccines: Challenges and Opportunities in Translation (Translational Medicine)

Sample text

Manici S, Sturniolo T, Imro MA, et al. Melanoma cells present a MAGE-3 epitope to CD4þ cytotoxic T cells in association with histocompatibility leukocyte antigen DR11. J Exp Med 1999; 189:871–876. 61. Zarour HM, Storkus WJ, Brusic V, et al. NY-ESO-1 encodes DRB1*0401-restricted epitopes recognized by melanoma-reactive CD4þ T cells. Cancer Res 2000; 60:4946–4952. 62. Jager E, Jager D, Karbach J, et al. Identification of NY-ESO-1 epitopes presented by human histocompatibility antigen (HLA)-DRB4*0101-0103 and recognized by CD4þ T lymphocytes of patients with NY-ESO-1-expressing melanoma.

14. Barton LF, Cruz M, Rangwala R, et al. Regulation of immunoproteasome subunit expression in vivo following pathogenic fungal infection. J Immunol 2002; 169:3046–3052. 15. Niedermann G. Immunological functions of the proteasome. Curr Top Microbiol Immunol 2002; 268:91–136. 3d] [18/2/08/12:14:55] [1–30] 22 Le´vy et al. 16. Kessler JH, Beekman NJ, Bres-Vloemans SA, et al. Efficient identification of novel HLA-A*0201–presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis.

He Y, Zhang J, Donahue C, et al. Skin-derived dendritic cells induce potent CD8þ T cell immunity in recombinant lentivector-mediated genetic immunization. Immunity 2006; 24:643–656. 159. Sharkey MS, Lizee G, Gonzales MI, et al. CD4þ T-cell recognition of mutated B-RAF in melanoma patients harboring the V599E mutation. Cancer Res 2004; 64:1595–1599. 160. Yotnda P, Firat H, Garcia-Pons F, et al. Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia.

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