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Proc. Nat. Acad. S c i . , 1981, 78, 1227-1241. ; Hornung, R. Mol. C e l l . , 1980, 19, 243-251. ; C a t t e r a l l , W. Mol. , 1979, 15, 174178. , Mol. , 1979, 15, 174-178. , J. Gen. Physiol. 1975, 6 6 , 169-182. ; Herchuelz, H. Biochem. Pharma col. 1981, 30, 3291-3294. , J. Physiol. Paris. 1980, 76, 515-522. ; Parker, I . , Proc. Roy. Soc. Lond. , 1980, 211, 143-150. ; Parker, I . , Biomed. , 1981, 2, 587-589. RECEIVED June 10, 1982. 3 Effects of Calcium Inhibitory Compounds upon the Cardiovascular System WILLIAM W.
Ratio (-) : (+) 10 55 3 55 10 100 56-58 15 5 59 SMOOTH MUSCLE Guinea-pig ileum, ACh Ca Rat p o r t a l v e i n , aorta, Ca /K + NE Rat v a s d e f e r e n s , Rabbit 2 + Ca 2 + /K + 2 + /K + 10 180 60 10 60 25 60 40 60 60 61 2. P. P. 3x10" Me CH Me. ch002 Ur -σ •Ε 8 ο ιο eι Ο Τ 7 1 6 5 6 7 8 -log ICgQ (Response) 9 10 Figure 5. Correlation between affinities of a series of 2,6-dimethyl-3,5-dicarbomethoxy-4-substituted phenyl-1,4-dihydropyridines measured as their abilities to displace specific Η-nitrendipine binding in a microsomal preparation of guinea pig ileal longitudinal smooth muscle (IC , binding) and to inhibit by 50% the sustained mechanical response of the intact muscle to muscarinic receptor stimulation (IC , response).
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