Chemistry

Calcium Regulation by Calcium Antagonists by Ralf G. Rahwan & Donald T. Witiak

By Ralf G. Rahwan & Donald T. Witiak

content material: Calcium antagonists : class and houses / Winifred G. Nayler --
Chemical pharmacology of calcium antagonists / D.J. Triggle --
results of calcium inhibitory compounds upon the cardiovascular procedure / William W. Muir --
keep an eye on of intracellular calcium in gentle muscle / E.E. Daniel, A.K. Grover, and C.Y. Kwan --
Calmodulin : an intracellular Ca² receptor protein / Charles O. Brostrom, Margaret A. Brostrom, and Donald J. Wolff --
Pharmacology of intracellular calcium adversarial methylenedioxyindenes / Ralf G. Rahwan and Donald T. Witiak --
Pharmacologic outcomes of calcium interactions with opioid alkaloids and peptides / David Chapman and E. Leong method --
Calcium antagonism and antiepileptic medicinal drugs / James A. Ferrendelli --
dating of cyclic nucleotides and calcium in platelet functionality / G.C. Le Breton, N.E. Owen, and H. Feinberg --
Suppression of atherogenesis with a membrane-active agent : nifedipine / Philip D. Henry and Karen Bentley --
Calcium and the secretory procedure / J.L. Borowitz, David E. Seyler, and Celeste C. Kuta.

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Proc. Nat. Acad. S c i . , 1981, 78, 1227-1241. ; Hornung, R. Mol. C e l l . , 1980, 19, 243-251. ; C a t t e r a l l , W. Mol. , 1979, 15, 174178. , Mol. , 1979, 15, 174-178. , J. Gen. Physiol. 1975, 6 6 , 169-182. ; Herchuelz, H. Biochem. Pharma­ col. 1981, 30, 3291-3294. , J. Physiol. Paris. 1980, 76, 515-522. ; Parker, I . , Proc. Roy. Soc. Lond. , 1980, 211, 143-150. ; Parker, I . , Biomed. , 1981, 2, 587-589. RECEIVED June 10, 1982. 3 Effects of Calcium Inhibitory Compounds upon the Cardiovascular System WILLIAM W.

Ratio (-) : (+) 10 55 3 55 10 100 56-58 15 5 59 SMOOTH MUSCLE Guinea-pig ileum, ACh Ca Rat p o r t a l v e i n , aorta, Ca /K + NE Rat v a s d e f e r e n s , Rabbit 2 + Ca 2 + /K + 2 + /K + 10 180 60 10 60 25 60 40 60 60 61 2. P. P. 3x10" Me CH Me. ch002 Ur -σ •Ε 8 ο ιο eι Ο Τ 7 1 6 5 6 7 8 -log ICgQ (Response) 9 10 Figure 5. Correlation between affinities of a series of 2,6-dimethyl-3,5-dicarbomethoxy-4-substituted phenyl-1,4-dihydropyridines measured as their abilities to displace specific Η-nitrendipine binding in a microsomal preparation of guinea pig ileal longitudinal smooth muscle (IC , binding) and to inhibit by 50% the sustained mechanical response of the intact muscle to muscarinic receptor stimulation (IC , response).

Pharmacol. 1982, 75, 229-236. ; Wehinger, E. Angewandte Chemie. Int. Ed. 1981, 20, 762-769. ; Macko, E. J. Med. Chem. 1974, 17, 956-965. ; Murakami, M. Chem. Pharm. B u l l . Tokyo, 1979, 27, 1426-1440. J. "Calcium and Drug Action", G. , Ed. 3. , 1979, Naunyn-Schmied. Arch. Pharma­ col. 1979, 310, 69-78. , Arz. Forsch. 1979, 29, 226-229. ch002 49. ; Vater, W. Arz. Forsch. 1981, 3 1 , 407-409, 50. , J. Med. Chem. 1980, 23, 1442-1444. 51. J. J. Med. Chem. 1982, 25, 126-131. 52. ; Kaufmann, R. NaunynSchmied.

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