C-Type Lectin Receptors in Immunity by Sho Yamasaki

By Sho Yamasaki

The ebook offers the most recent findings on C-type lectin receptors, concentrating on person receptors and their signaling. in recent times there were nice advances within the knowing of the functionality of those receptors as a newly rising relations of pattern-recognition receptors (PRRs) for pathogen-associated molecular styles (PAMPs) and damage-associated molecular styles (DAMPs). Comprising 4 elements: ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearing Receptors; and different Receptors and comparable subject matters, this finished evaluate covers a extensive variety of C-type lectin receptors. The up-to-date details on C-type lectin receptors and their ligands supplied will attract a large readership, from easy immunologists to physicians and surgeons. additionally, sections on novel drug improvement make this a worthwhile source for pharmaceutical scientists.

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20081445 Wevers BA, Kaptein TM, Zijlstra-Willems EM, Theelen B, Boekhout T, Geijtenbeek TB, Gringhuis SI (2014) Fungal engagement of the C-type lectin mincle suppresses dectin-1induced antifungal immunity. Cell Host Microbe 15(4):494–505. 2014. 008 World Health Organization Global tuberculosis report 2015 (2015) Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T (2008) Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol 9(10):1179–1188. 1038/ni. 1651 Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, Uno J, Hirabayashi J, Mikami Y, Takeda K, Akira S, Saito T (2009) C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia.

M114. 566489 Heitmann L, Schoenen H, Ehlers S, Lang R, H€olscher C (2013) Mincle is not essential for controlling Mycobacterium tuberculosis infection. Immunobiology 218(4):506–516. doi:10. 005 Hunter RL, Olsen MR, Jagannath C, Actor JK (2006) Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease. Ann Clin Lab Sci 36(4):371–386 32 M. Nagata et al. Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S (2009) Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.

However, whether intact virions physically interact with TLR2 and TLR4 is still unknown. It is interestingly observed that even HSV-1 can signal via the TLR2, this receptor does not mediate recognition of HSV glycoproteins (Reske et al. 2008). This observation suggests that TLR2 may associate with other receptor on cell surface to recognize the glycoproteins on HSV. We have shown that CLEC5A physically interacts with flaviviruses, and flaviviruses can activate CLEC5A directly to trigger downstream signaling.

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