Health Policy

Bioscience : lost in translation? : how precision medicine by Richard Barker

By Richard Barker

Clinical innovation because it stands this day is essentially unsustainable. there's a widening hole among what biomedical learn delivers and the effect that it truly is at present attaining, when it comes to sufferer profit and wellbeing and fitness process improvement.

This publication highlights the worldwide challenge of the useless translation of bioscience innovation into well-being process advancements and its outcomes, analyses the underlying causative components and gives strong prescriptions for switch to shut the space. It contrasts the growth in biomedicine with different parts of clinical and technological endeavour, akin to details expertise, during which there are quicker and extra trustworthy returns for society from medical enhance. It asks looking out questions on even if society is correct to count on a lot from biomedicine and why we now have turn into conversant in such negative returns.

Throughout the publication, strategies reminiscent of stratified medication, open innovation, adaptive improvement and customized adherence are mentioned and defined in phrases available to the non-specialist, and their impression at the innovation hole explored.

By utilizing examples within which bottlenecks have avoided growth, reminiscent of dementia and antibiotic-resistant infections, and within which those boundaries were conquer, equivalent to HIV therapy, Bioscience - misplaced in Translation? lays out a method for advancing the innovation method, proposing feedback for the way well-being platforms can stream from being passive recipients of innovation to being lively contributors in development.

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Extra resources for Bioscience : lost in translation? : how precision medicine closes the innovation gap

Sample text

The genomics of complex, chronic diseases like diabetes will probably lag behind by several years, especially as non-​genomic factors associated with human behaviour seem to be more significant in determining disease risk and development. 3 Acceleration in genomic science. 4 Growth in genomic analysis technologies (up to 2014).  2015. 18 Bioscience—Lost in Translation? on age, sex, and body mass index (BMI)6. In the section entitled ‘Probing epigenomic control of gene expression’ we will see some of the ‘epi-​genetic’ factors at play.

Chapter 3 analyses the disappointing progress in turning these discoveries into practical benefit for patients and society. It identifies five major gaps in the translation process: from the focus of much of the research (T0), through its fitful transition to disease-​relevant discovery (T1), the high fallout rate in clinical development (T2), the lack of adoption and adherence of approved products (T3), to the failure to learn from their use across the healthcare system (T4). It concludes that—​if we are to reap the harvest of new products and medical advance from the scientific investments just described—​a major overhaul is needed of the translation process itself.

A 32 Bioscience—Lost in Translation? Summary of Chapter 2 Life sciences has seen its own exponential progress, both in scientific advances and valuable enabling technology. From the quickening pace and plummeting cost of gene sequencing to the emergence of new data-​mining tools to unravel the accumulated results of past decisions, the last 20 years have been unprecedented in the exploitable advances brought by research. We have the tools and insights to trace disease from the genetics and epigenetics that typically underlie it, through the proteins that represent intervention options to the means of creating molecules, diagnostics, and devices based on those insights.

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