By D. Kabelitz, T. Pohl, K. Pechhold (auth.), Guido Kroemer, Carlos Martinez-A. (eds.)
In any move in their existence, immune cells, specifically T and B lymphocytes, are faced with an important selection: to proceed their lifestyles or to devote a type of metabolic suicide that's often called apoptosis or programmed cellphone dying. unlike such a lot philosophers, lymphocytes and their precursors are consistently liable to suicide, and it even seems that the standard explanation for T or B mobilephone removal is suicide instead of dying from typical explanations, injuries or homicide. This booklet offers an unlimited evaluation of lymphocytes suicide: exterior triggers and inner factors resulting in suicidal impulses, accomplices in self-destruction, guns implicated in self-execution, elimination of lifeless our bodies and pharmacological prevention of suicide. lots of the chapters during this booklet are dedicated to the body structure of apoptosis. The objective is to unmask the exterior triggers of apoptosis, get to the bottom of the sign transduction professional cesses concerned therein and describe the position of oncogenes, "death genes" and effector molecules within the apoptotic cas cade. the remainder chapters care for the pathophysiologi cal facets of lymphocyte apoptosis, particularly, as a bunch contribution to HIV-induced lymphopenia, and healing concepts for the avoidance of lymphocyte loss of life. we're convinced that this compendium will give a contribution to the exploration of mobile suicide, not just from a simple scientist's perspective but additionally with reference to the potential medical implications of apoptosis (dys)regulation. faraway from having a dismal impression at the reader, mobile suicide may perhaps therefore offer a resource of either highbrow pleasure and healing inspiration.
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Although somewhat surprising in view of the studies mentioned above, our observations have been recently supported by the finding that, while antisense e-mye oligonucleotide indeed prevented anti-Ig inhibition of WEH 1-231 cells, such a treatment actually resulted in stabilization of c-mye mRNA and of e-mye protein expression (Fischer et al. 1994). Although such unexpected functions of an antisense oligonucleotide molecule may have to be further examined, together with our own observations these findings imply that sustained levels of B Cell Activation and Apoptosis 29 c-Myc proteins are reqllired to prevent anti-Ig-induced apoptosis in this immature B cell line.
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