By Joachim R. Kalden, Martin Herrmann
This is often the 1st accomplished publication in regards to the courting among apoptosis and autoimmune illnesses. It deals a different up to date evaluate on learn effects at the faulty execution of apoptosis and the unfinished clearance of apoptotic cells. The molecular and mobile mechanisms concerned are defined intimately. As a potential end result of apoptotic disorder, the improvement of serious autoimmune ailments (e.g., rheumatoid arthritis, systemic lupus erythematosus) is mentioned. An outlook on destiny study themes contains the assessment of novel healing techniques.
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Additional resources for Apoptosis and Autoimmunity: From Mechanisms to Treatments
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The route leading from ER stress to caspase-12 activation, however, remains unclear. There is evidence, however, suggesting that release of intracellular calcium stores associated with ER stress activates the protease calpain, which in turn can activate caspase-12 and lead to apoptosis . 10 Compensatory Caspase Activation: A Caveat to Knockout Analysis Although the generation of knockout animals has vastly increased our knowledge of the cellular apoptotic machinery, one difficulty in assessing the contributions of individual proteins has been the ability to preserve function by the compensatory activation of related proteins.
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