Immunology

Antimicrobial Peptides and Human Disease (Current Topics in by William Shafer

By William Shafer

Microbes are in our midst quickly after start. fortunately, the variety of innocuous (and frequently useful) microbes a ways outnumber those who could do us damage. Our skill to ward-off pathogens in the environment, together with those who can colonize our external and/or inside surfaces, relies on the integrative motion of the innate and adaptive immunity structures. This quantity of CTMI, entitled Antimicrobial Peptides and Human ailment, is devoted to the position of antimicrobial peptides (AMPs) within the innate host security approach of homo sapiens.

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However, it is not clear whether this is a direct down-regulation of expression, or a consequence of denuding the epithelium, with reduced expression in the replacement cells. 38 D. M. E. Bowdish et al. 1 Re-epithelisation and Proliferation Early experiments with host defence peptides demonstrated that many of these peptides have mitogenic effects on a variety of cells and cell lines. Since modest to high concentrations of host defence peptides are found at sites of infection and inflammation, it has been hypothesised that this proliferative effect might be involved in wound healing and re-epithelisation.

46 Mechanisms . . . . . . . . . . . . . . . . . . . . . . 50 4 Conclusion . . . . . . . . . . . . . . . . . . . . . . 53 References . . . . . . . . . . . . . . . . . . . . . . . . . 55 Abstract Host defence peptides are a conserved component of the innate immune response in all complex life forms. In humans, the major classes of host defence peptides include the α- and β-defensins and the cathelicidin, hCAP-18/LL-37. These peptides are expressed in the granules of neutrophils and by a wide variety of tissue types.

Biochemistry 40:4211–4221 135. Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME (2002) Homodimeric thetadefensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem 277:3079–3084 136. Valore EV, Ganz T (1992) Posttranslational processing of defensins in immature human myeloid cells. Blood 79:1538–1544 137. Valore EV, Martin E, Harwig SS, Ganz T (1996) Intramolecular inhibition of human defensin HNP-1 by its propiece.

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