The Antibodies by Maurizio Zanetti, Donald J. Capra

By Maurizio Zanetti, Donald J. Capra

From diagnostic instruments to remedy opposed to melanoma, infections and autoimmune ailments, antibodies serve many reasons, but our wisdom of them continues to be incomplete. The Antibodies: quantity 7 maintains with a entire evaluate of subject matters of up to date curiosity together with significant breakthroughs corresponding to the appearance of monoclonal antibodies and the improvement of recent ideas of antibody engineering that experience stored antibodies on the vanguard of immunology and clinical technological know-how. whereas interpreting the ground-breaking discoveries of the final 20 years this publication additionally revisits extra conventional features of the sector to offer an holistic method of this more and more well known zone of medication.

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Exp. Med. 193, F41–6. 22 MARYSE BRAIT et al. 3. A. (1998). The role of the B cell receptor V region in peripheral B cell survival. Eur. J. Immunol. 28, 2685–93. 4. Marshall, E. (1996). Disputed results now just a footnote. Science 273, 174–5. 5. Cohn, M. (1994). The wisdom of insight. Ann. Rev. Immunol. 12, 1–62. 6. , Jr. (2001). Inaugural Article: How the immune system works to protect the host from infection: A personal view. Proc. Natl. Acad. Sci. USA. 98, 7461–8. 7. , and Coutinho, A. (1986).

Much is known about the Ig isotypes and Fc structure-function relationships so that the Fc can be selected/modified for a chosen purpose. For example, the Fc can be selected from various subclasses depending on the desired property such that an IgG3-IL-2 fusion (which has the extended half-life of 7 hr) has increased binding to FcR on killer cells [66]. The appropriate sites of Fc can also be modified to reduce complement or FcR binding activity [26]. ACKNOWLEDGMENTS We acknowledge the support of JDRF, NHMRC and CRC-VT.

Immunol. 13, 123–32. 74. D. (1989). Structural characterization of antiidiotypic antibodies. Evidence that Ab2s are derived from the germline differently than Ab1s. J. Exp. Med. 169, 519–33. 75. D. (1991). Polymorphism in V kappa 10 genes encoding L chains of antibodies bearing the Ars-A and A48 crossreactive idiotypes. Immunogenetics 34, 231–41. 76. H. (1982). Regulation of azophenylarsonate-specific repertoire expression. 1. Frequency of cross-reactive idiotype-positive B-cells in A/J and BALB/c mice.

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