Anti-Angiogenic Therapy in Ophthalmology by Andreas Stahl

By Andreas Stahl

This booklet presents a concise evaluate over the pathology of retinal angiogenic illnesses and explains why anti-angiogenic treatment is efficacious in such a lot of sufferers. The reader is guided in the course of the numerous scientific symptoms for anti-angiogenic remedy and made conscious of its advantages in addition to present demanding situations and boundaries. it really is defined how, seeing that its advent for the remedy of exudative age-related macular degeneration in 2006, anti-angiogenic treatment has revolutionized the best way we deal with a number ocular illnesses. the entire authors are demonstrated specialists of their respective fields who percentage their large wisdom and scientific adventure with the reader. This publication is either a beneficial creation to anti-angiogenic treatment in ophthalmology and a day by day significant other for all ophthalmologists seeing sufferers with probably the most generic retinal diseases.

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2011; Boyer et al. 2009). , averaging greater than six injections in 12 months as in the CATT and HARBOR studies) initial gains are maintained to the 12-month mark (Martin et al. 2011; Busbee et al. 2013), although regular 4-weekly treatment regimes yielded overall better results (Martin et al. 2012; Busbee et al. 2013). The mean gain in VA reported with regular 4-weekly regimes across phase III clinical trials has varied between 7 and 11 Early Treatment Diabetic Retinopathy Study (EDTRS) letters (Lanzetta et al.

Central zone II (or posterior zone II) is defined by a circle around the ONH with three times the diameter ONH—fovea. Peripheral zone II (or anterior zone II) is a circle around the ONH reaching the ora serrata nasally. Zone III refers to the crescent-shaped remaining retina on the temporal side. The ROP zones are schematically depicted in Fig. 2. Stage 4 and 5 of ROP are characterized by partial or complete retinal detachment and can be avoided in most cases by timely treatment at earlier stages.

In most infants, this centrifugal growth progresses without significant disturbance and the ophthalmologist can identify an increasing area of the retina becoming vascularized from visit to visit. However, in some infants the hypoxic environment in the peripheral retina is so severe that pathologically high levels of the angiogenic growth factor VEGF are produced (Sonmez et al. 2008; Velez-Montoya et al. 2010). This leads to a breakdown of natural growth factor gradients in the retina and to aberrant and uncontrolled growth of retinal vessels.

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