Advances in Pharmacology, Vol. 39 by J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle

By J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle

Each one quantity of Advances in Pharmacology offers a wealthy choice of reports on well timed themes. Emphasis is put on the molecular bases of drug motion, either utilized and experimental.

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Bryan, T. , Hamilton, S. , Thibodeau, S. , and Kinder, K. W. (1992). APC mutations occur early during colorectal tumorigenesis. Nature (London) 359, 235-237. Rao, C. , and Reddy, B. S. (1995). Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. Cancer Res. 55, 1464-1472. Reddy, B. , and Kelloff, G. (1987). Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development.

N . Engl. J. Med. 325, 1593-1596. , and Valanzano, R. (1993). Sulindac in familial adenomatous polyposis. Lancet 342, 1120-1120. , and DuBois, R. N. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2. ) 83,493-501. Vane, J. (1994). Towards a better aspirin. Nature (London)367, 215-216. Waddell, W. , and Loughry, R. W. (1983). Sulindac for polyposis of the colon. J. Surg. Oncol. 24, 83-87. Waddell, W. , Gasner, G. , Cerise, E. , and Loughry, R.

One of the earliest observations made about MMTV was that pregnancy or glucocorticoids and progesterone dramatically increased viral transcription and, as a consequence, virus production, as much as SO-fold (Bittner, 1958). The progestin/glucocorticoid receptor antagonist RU486 inhibits this induction. The DNA sequences controlling the hormone responsiveness, termed the glucocorticoid response elements (GRE),are responsible for the upregulation of virus production that occurs during lactation, when glucocorticoid and progesterone levels are elevated (Yamamoto, 1985) (Fig.

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