Immunology

25 Years of P53 Research by Pierre Hainaut, Klas G. Wiman

By Pierre Hainaut, Klas G. Wiman

P53 has emerged as a key tumor suppressor and critical aim for novel melanoma remedy. This booklet, written through world-leading p53 researchers together with lots of those that have formed the sector over the last 25 years, offers exact insights into the development of the sector and the customers for higher melanoma analysis and remedy sooner or later.

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2003. 2: 406-415. , Rechavi G. A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the co-activator Zac-1. Oncogene, 2002. 21: 1469-1476. J. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associtaed with the same 54kd cellular protein in transformed cells. Cell, 1982. 28: 387-394. J. S. p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.

Anderson M. , Tegtmeyer P. Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation. Mol Cell Biol 1997; 17:6255-64. , Anderson C. W. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001; 268:2764-72. Avantaggiati M. , Levine A. , Kelly K. Recruitment of p300/CBP in p53-dependent signal pathways. Cell 1997; 89:1175-84. , Mulder F. , Yi G. , Kay L. , Arrowsmith C. H. Latent and active p53 are identical in conformation.

Prives C. p53 in the cytoplasm: a question of overkill? Cell 2004; 116:487-9. , Manfredi J. , Marshak D. , Prives C. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev 1993; 7:2565-74. Barlev N. , Chehab N. , Harris K. , Halazonetis T. , Berger S. L. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell 2001; 8:1243-54.

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