2011-2012 Basic and Clinical Science Course, Section 4: by Robert H. Rosa Jr., MD

By Robert H. Rosa Jr., MD

This quantity is split into elements: half I, Ophthalmic Pathology; and half II, Intraocular Tumors: scientific elements. half I makes use of a hierarchy that strikes from common to precise to aid derive a differential prognosis for a particular tissue. half II is a compilation of chosen medical points of significance to the overall ophthalmologist. Following half II are the yank Joint Committee on melanoma 2010 staging kinds for ocular and adnexal tumors. This revised textual content comprises various new pathologic and scientific pictures. significant revision 2011-2012.

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Additional info for 2011-2012 Basic and Clinical Science Course, Section 4: Ophthalmic Pathology and Intraocular Tumors (Basic & Clinical Science Course)

Sample text

Thus, for the clinician making a clinicopathologic diagnosis, PCR should be used mainly to derive supplementary information. See also Part III, Ge netics, in BCSC Section 2, Fundamentals and Principles of Ophthalmology. Microarray Microarrays are used to survey the expression of thousands of genes in a single assay, the output of which is called a gene expression profile. Using microarray technology, scientists and clinicians can atte mpt to understand fundamental aspects of growth and development, as well as to explore the molecular mechanisms underlying normal and dysfun ctional biological processes and elucidate the ge netic causes of ma ny human diseases.

The advantage of this method is that it actuall y shows the percentages of particular cells in a specimen. Disadvantages are the fail ure to show the location and distribution of these cells in tissue and the possibility of sampling erro rs. Depending on th e number of cells in the sample and on clinical information, the flow cytometrist chooses the panel of antibodies to be tested. Flow cytometric data shou ld therefore be used as an adjunct to morphologic H&E and sometimes immunohistochemistry interpretation.

Peripheral neuroectodermal tu mors [PNETJ). that demonstrate characteristic translocations. Based on the results. treatment can be directed and prognostic features associated with certain mutations and translocations. Hicks J, Mierau GW The spec trum of pediatric tumors in infancy, childhood, and adoles· cence: a comprehensive review with emphasis on special techniques in diagnosis. ' 2005;29(3 -4),175-202. Oostlander AE, Meijer GA, Ylstra B. Microarray-based compa rative genomiC hybridization and its applications in human genetics.

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